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I’m a generally healthy 23 year old female who is having some problems with hypokalemia.
For the past 10 months I have been having trouble keeping my potassium at a normal level (above 3.5). Five times I have ended up in the ED or hospitalized for IV replacement after levels around 2.7
Other times I have caught it earlier around 3.1 and was able to get it back up after ED visits for some oral replacement.
After a the first few times this happened my doctor put me on a high potassium diet, and when it continued to happen I was put on 10meq of potassium daily and then when that didn’t work either it was increased to 20meq daily, however I am still having trouble keeping my potassium at normal level at times.
Most of the time my potassium is around 3.4-3.7, but randomly it will begin to drop and drop quickly to the 2.7. When it gets to around 3.0 I start to get really nauseated, shaky and generally feel like crap, when it gets down to the 2.7 I have usually started vomiting which only makes it drop lower (I do not vomit before it initially starts to plunge though so the low levels isn’t caused by vomiting).
I am normal weight, generally healthy, and my blood pressure always lower, 90/60 ( I know that there is one thing that can cause the low potassium levels but my doctors do not think I have it because it is associated with high blood pressure).
I really want to know why this is happening because when it happens I feel like crap, the IV potassium replacement is not any fun (many of my veins are shot from all the potassium infusions, once they had to use my foot) and I always feel horrible for days afterwards.
Since being on the high potassium diet and 20meq of potassium daily I have had less of these episodes, but they are still happening.
Gender: Female
How old are you?: 23
How long has this been going on?: More than a month
Check all symptoms you are currently experiencing: None
Describe associated symptoms not listed above:
During these episodes I first feel weak, leg cramps, nauseated then I get shaky, and begin to have muscle contractions in my hands and finally begin to vomit.
What have you done so far to remedy this condition? Please include tests and relevant studies here.
Potassium is generally normal (3.4-3.7) with these occasional drops to 2.7-3.1
Magnesium is always normal.
Thyroid is normal.
Abdominal/Pelvic CT is normal.
Only thing that works once it gets really low (2.7) is a few days in the hospital getting IV potassium infusions.
Please list any chronic medical problems and also list any prior surgery (lacerations don't count!): Hemicrania Continua: treated with an occipital nerve stimulator implant
Neurocardiogenic Syncope: Loop recorder implant and explant surgeries.
Inappropriate Sinus Tachycardia
3 EP studies
Check all conditions present in your immediate family... :
Asthma / Lung Problems
Cardiac Disease
Diabetes
Hypertension
Stroke
Please list any medications you are currently taking (and dosage if known) ::
Bisoprolol 10mg 1x a day (for inappropriate sinus tachycardia)
Zoloft 100mg 1z a day (for neurocardiogenic syncope)
Multi-vitamin 1x a day
Potassium 20 meq 1x a day
Vitamin D 50,000IU 2x a week (vitamin D level one month ago was 13)
Ambien CR 12.5mg 1x day
When was your last menstrual cycle?: 1 week ago
Are you currently using or do you have a history of tobacco use?: No
Are you currently using or do you have a history of illegal drug use?: No
Please describe your alcohol consumption :: Occasionally
HOW QUICKLY DO YOU NEED THIS TO BE ANSWERED?: Within the next few days
So that we can serve you best, please try to tell us your top three things you wish to be addressed in our response. You will likely get more than you ask for, but we wish to understand your priorities.
Why does my potassium level drop like this?
My doctors seem to have given up on finding a cause for this and are just treating as it happens, should I be pressing for answers or should I just accept that this is what my body does?
Any additional tests I should ask my doctor for?
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Well, as an Emergency Doctor I see disorders of potassium all the time. But it is rare indeed for me to see someone like yourself.... someone in pretty good health, with persistent, unexplained hypokalemia. And make no mistake.... this is serious business. Hypokalemia in the extreme is terribly dangerous, and you say the only way for you to get repleted and feel well is to have IV runs of potassium. This is going to my contribution here and I'm going to let my good Internal Medicine docs go a little more in depth... It is, after all, what they do. ER docs are shallow, Internal Medicine docs are deep. I am making a bit of a joke but an ER doc knows a little about a lot, and the Internist knows a lot about a little (if you consider all of adult medicine a little.... but I digress).
Disorders of potassium can be disorders of absorption, excretion, or intake. The strange fact about your case is that you do not seem to properly absorb the oral potassium. So I wonder if you have an absorption problem. In the ER if someone is low on potassium then the quickest way to get them back to where they need to be is to give the potassium orally, usually mixed in a liquid.
The other likely cause would be a problem in the kidney itself, something called 'renal tubular acidosis', and a problem with the kidney's ability to hold onto potassium would also make sense in your case.
So with hope my Internal Medicine colleagues ride to my rescue here, I am concerned about your intestinal absorption of potassium since the oral supplementation does not seem to work AND also concerned this may be a kidney problem. If you have not been referred to a nephrologist then that would be a good next step.
None of the medicines you are on are potassium-wasters but just so you know, people who take certain diuretic pills off label... often to lose weight, can stay very low on potassium. People who self induce vomiting or take laxatives can have this problem too. And, finally, if you live on black licorice then that may honestly be the culprit.
Please feel free to ask questions in the comment section and I will stand by for more insightful commentary from my fellow docs.
MD STAT ER DOC 1
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